Release date: 2007-01-19

Scientists from the Weizmann Institute have made a breakthrough in the fight against antibiotic resistance by combining two natural defense mechanisms used by organisms to combat bacteria and fungi. This innovative approach could lead to the development of more effective antibiotics, offering new hope in the ongoing battle against drug-resistant infections.

The human body naturally produces two types of antibacterial agents. One is a "magnetic" type known as antimicrobial peptides (AMPs), which carry a positive charge and are attracted to the negatively charged surfaces of bacteria. These peptides work by disrupting the bacterial cell membrane. The other is a "cleansing" agent called lipopeptides, found primarily in bacteria and fungi. These molecules contain a fatty acid chain that helps break down the lipid membranes of microbial cells.

Researchers led by Prof. Yehr Xie at the Weizmann Institute of Biochemistry successfully merged the key functions of AMPs and lipopeptides, creating a synthetic compound that not only carries a positive charge but also has the ability to dissolve fats. This hybrid molecule represents a powerful new tool in the fight against resistant pathogens.

By modifying the length of the fatty acid chains and the sequence of positively charged amino acids, the team developed a range of synthetic lipopeptides with varying targets. Some are effective against both bacteria and fungi, while others are more specific to one type of microorganism. The researchers are also working on designing even shorter versions—peptides containing just four amino acids—which could be easier to produce and more cost-effective.

The reduced length of these synthetic peptides offers several advantages. Not only does it simplify the manufacturing process, but it also allows for the creation of more targeted treatments tailored to specific infections. As a result, this discovery holds great promise for the future of medicine, potentially leading to a new generation of antibiotics with broader applications and improved efficacy.

—— Information from: Meditech Medical Network

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Antiviral:

Antiviral drugs are a class of medication used specifically for treating viral infections. Like antibiotics and broad-spectrum antibiotics for bacteria, most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development.


Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections. They should be distinguished from viricides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Antivirals also can be found in essential oils of some herbs, such as eucalyptus oil and its constituents.Related Products:antiviral drugs,anti-cancer drugs.


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Anticancer, or Antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy.

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