LCZ696 (Valsartan/sacubitril) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi).
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Lcz696 Intermediates,Cas 1426129-50-1,Cas 1012341-50-2,High Purity Lcz696 Intermediate Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
(2) Do not use engine oil instead of brake fluid Brake fluid has good solubility and corrosion, and is less prone to sedimentation. The engine oil does not have the above characteristics. If it is used in place of brake fluid, it will easily produce sedimentation, and it will cause brake system rubber components to produce Expansion causes brake failure.
(3) Do not use diesel oil instead of diesel oil. The diesel oil has a lower viscosity than diesel oil and has a high ignition temperature. If diesel oil is used instead of diesel, the diesel engine will not only be difficult to start, but will also cause increased wear of cylinders and pistons.
It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe.
We produce a series of complete intermediates for LCZ696, intermediate I (CAS No. 1426129-50-1) and intermediate II (CAS No. 1012341-50-2) etc.
(1) Do not use engine oil instead of gear oil. Engine oil and gear oil have low viscosity and weak wear resistance and load capacity. If oil is used instead of gear oil, the transmission gear will not be well lubricated, which will cause severe gear wear of the transmission system.