Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
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Palbociclib Intermediates,Cas 571188-59-5,Cas 1013916-37-4,Cas 1016636-76-2 Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
It was reviewed and approved under the Food and Drug Administration`s (FDA) accelerated Priority Review and Breakthrough Therapy designation programs on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor positive advanced breast cancer.
We produce a series of complete intermediates for Palbociclib, intermediate I (CAS No. 571188-59-5), intermediate II (CAS No. 1013916-37-4) and intermediate III (CAS No. 1016636-76-2) etc.
Persimmon fruit is a kind of respiration-changing fruit, and it is more sensitive to ethylene and easy to soften after picking, which brings great difficulties to storage, transportation and marketing. At present, the persimmon fruit storage and preservation techniques mainly have the following methods: Low temperature storage temperature is the main factor affecting fruit respiration. Low-temperature storage can effectively maintain the respiration of persimmon fruit, reduce the production and release of ethylene, inhibit the growth of pathogenic microorganisms, and prevent browning and decay. The persimmon's freezing point is generally around -2°C. The optimum storage temperature of persimmon fruit is (01) °C, and it is advisable to control the temperature variation at 0.5 °C. The persimmon fruits should be precooled immediately after they are harvested, and the fruit should be quickly reduced to 5°C and then gradually reduced to 0°C. In the storage practice, the combination of air-conditioning and low-temperature refrigeration is currently the most modern storage method for persimmon fruits at home and abroad. Atmosphere storage of persimmon fruit can tolerate higher carbon dioxide, suitable for controlled atmosphere storage. Atmosphere storage can be divided into CA storage and MAP storage. For CA storage, the perennial fruit has the best oxygen concentration of 3% to 5% and carbon dioxide of 3% to 8%. Atmosphere storage can be stored for 3 to 4 months. MAP is spontaneously stored in the atmosphere for up to 6 months. Decompression storage is also a form of controlled atmosphere storage. It is to reduce the pressure and inhibit the ripening and aging of fruits. Preservation and Preservation Freshness The preservation and preservation of fruits in recent years are the focus of research by many scientific and technological workers. There are chemical agents and natural preservatives. Mainly chitosan, salicylic acid, deacetylation of chitin and so on. Its role can reduce ethylene release and respiratory intensity, delay ripening and softening, and inhibit ABA accumulation.