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Peptide Hormones Mgf for Bodybuilding From Lab
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Model NO.: APICustomized: CustomizedSuitable for: AdultPurity: >98%Supply Ability: 1000 Kits Per MonthAppearance: White PowderName: Myostatin Gdf-8Transport Package: Plastic Tube, VialOrigin:Â
Product name:Myostatin GDF-8
Purity:95%
Specification:1mg/vial
Appearance:White powder
Storage:Dry Cool Place
Grade:Medicine Grad
Product Description
Myostatin
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
 Discovery and sequencing
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
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Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
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Lyophilized PeptideÂ
Name
CAS No.
SpecificationÂ
Name
CAS No.
SpecificationÂ
Â
Â
0.5mg/vial
1mg/vial
2mg/vial
5mg/vial
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62304-98-7
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MTI
75921-69-6
5mg/vial
10mg/vialPEG-MGF
Â
2mg/vial
ipamorelin
170851-70-4
1mg/vial
2mg/vial
5mg/vial
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Â
1mg/vial
CJC-1295
863288-34-0
2mg/vial
5mg/vial
10mg/vialAOD-9604
221231-10-3
2mg/vial
CJC-1295DAC
Â
2mg/vial
5mg/vial
10mg/vialPT141
32780-32-8
10mg/vial
Hexarelin
140703-51-1
2mg/vial
Follistatin 315
Â
1mg/vial
Â
946870-92-4
0.1mg/vial
1mg/vialFollistatin 344
Â
1mg/vial
pentadecapeptide BPC 157
137525-51-0
2mg/vial
5mg/vialGDF-8
Â
1mg/vial
GHRP-2
158861-67-7
5mg/vial
10mg/vialGonadorelin
34973-08-5
2mg/vial
5mg/vial
10mg/vial
GHRP-6
87616-84-0
5mg/vial
10mg/vialsermorelin
86168-78-7
2mg/vial
Epitalon
307297-39-8
10mg/vial
DSIP
62568-57-4
2mg/vial
TB500
75591-33-4
2mg/vial
5mg/vialdermorphin
Â
10mg/vial
MGF
Â
2mg/vial
5mg/vialArgireline Acetate
616204-22-9
5mg/vial
Deslorelin
57773-65-6
20mg/vial
Â
Â
1000IU per vial
5000IU per vial
Selank
Â
5mg/vial
Tesamorelin
218949-48-5
2mg/vial
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Flavored tea
Specification: 10cmx10comx10cm
Origin: Hubei
Specification: 10cmx10comx10cm
Origin: Hubei
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