Ibrutinib is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK) that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinemia, a form of non-Hodgkin's lymphoma.
Ibrutinib Intermediates,Cas 330786-24-8,Cas 143900-44-1,High Purity Ibrutinib Intermediates Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
1 Forming cultivation tank leveling greenhouse soil, 1m from the back wall of the greenhouse with red brick building trough, facing north and south, with an internal diameter of 48cm, groove width of 12cm, groove spacing of 60cm, groove height of 15 ~ 20cm, the bottom of the groove is covered with a layer of 0.1 Mm thick polyethylene plastic film to prevent the spread of soil pests.
2 Preparation of cultivation substrates After research in our hospital showed that corn waste, wheat straw, mushroom residue, sawdust, waste cotton seed husk, slag and other product wastes are organically cultivated matrix materials. By mixing with soil organic fertilizer, the cultivation effect can be replaced. Higher cost of peat and vermiculite. Alternative organic matrix formulations are: 1 wheat straw: slag = 7: 3; 2 waste cotton: seed hull: slag = 5: 5; 3 wheat straw: sawdust: slag = 5: 3: 2; 4 corn stalk: mushroom residue: Slag = 3:4:3; 5 corn stover: sawdust: mushroom residue: slag = 4:2:1:3. The raw materials of the matrix should be disinfected, and solar disinfection and chemical disinfection can be used. The total amount of cultivation medium is 30 cubic meters/667 square meters.
Solar disinfection method: water is poured through the substrate in advance, so that the matrix water content exceeds 80%, covered with a transparent plastic film, select 3 to 5 days continuous sunny, closed greenhouse, high temperature disinfection by strong light.
Chemical Disinfection Method: Dispose of 1% potassium permanganate and ditergic bacteria 500 times before the planting, thoroughly sterilize the matrix tank inside and outside, and the matrix, and then close the greenhouse and fumigate with the chlorothalonil fumigant twice.
3 Variety selection Choose varieties with high disease resistance, high yield, good quality, strong resistance and wide adaptability. Domestic varieties include Zhongza 11, Jiahong 5, Shanghai 903, 908, etc.; imported varieties are Caruso, Bailey, Marva and so on.
4 Cultivation season 1 Early spring cultivation In early February, planting seedlings, planting in late March and harvesting in early May.
2 Late autumn cultivation Seedlings are planted in early August and planted in late August and harvested in late September.
5 Preparation before planting
5.1 15 days before the application of basal fertilization, 10 to 15 kg of sterilized chicken manure, 0.25 kg of urea, 1 kg of diammonium phosphate, and 1 kg of potassium sulphate shall be added to each 1 cubic meter of the substrate to fully mix the tank.
5.2 Finishing the Substrate First of all, turn the substrate up and down, and then use a water pipe to flood the substrate of each cultivation tank with a large amount of water to facilitate the absorption of the substrate. When the water disappears, the substrate will be evener.
5.3 Installing the Drip Irrigation Pipe Place the prepared drip irrigation pipe on the groove filled with the substrate, with the drip irrigation hole facing upward. Apply a layer of film on the drip tube to prevent evaporation of water to enhance drip irrigation.
6 Cultivation Management
6.1 Seeding seedlings Seeds are soaked in hot water of 55°C for 15 minutes, removed and put in 1% potassium permanganate solution for 10-15 minutes, washed out with clean water, and germinated at 28-32°C. 70% of seeds are sown in seedbeds or plugs, covered with plastic film to maintain humidity, and maintained at an ambient temperature of 25 to 28°C during the day and 15 to 18°C ​​at night. After the seedlings were unearthed, the plastic film was removed in time, depending on the seedlings and the water content of the substrate, and it was not poured on rainy days. Temperature management with conventional nursery, daytime 20 ~ 28 °C, night 10 ~ 15 °C. Seedlings with 7 leaves when planting.
6.2 colonization of each planting 2 rows, spacing 30cm, plant spacing 35cm, planting about 3,000 per 667 square meters, planting immediately after the planting amount of 500ml per plant water.
6.3 Management after planting 1 Temperature management According to the characteristics of tomato growth and development, the temperature management is carried out through ventilation and shade nets. The temperature is 25 to 30°C during the day and 12 to 15°C during the night, and the substrate temperature is maintained at 15 to 22°C. When the temperature of the substrate is too high, the temperature is decreased by increasing the number of times of watering, and when the temperature is too low, watering or pouring of warm water is used to increase the temperature of the ground.
2 Humidity management Measures such as reducing the number of watering, increasing the temperature, and prolonging the time of air release reduce the humidity in the greenhouse and maintain the relative humidity of the air at 60% to 70%.
3 Light Management Tomatoes require higher light conditions. The light transmittance can be increased by periodically cleaning the dust on the shed film, and the light intensity can be increased by hanging the light curtain.
4 Moisture management Watering begins 3 to 5 days after planting, once every 3 to 5 days, 10 to 15 minutes each time, watering in sunny morning, no watering on cloudy days, maintaining substrate humidity before flowering and setting 60% to 65 %, after flowering and fruit setting, the main promotion is to maintain the substrate humidity at 70% to 80%, and the irrigation volume must be timely adjusted according to climate change and plant size.
5 Fertilizers began to be topdressed 20 days after planting management, and top dressings were applied once every 10 days. Only chicken manures were pre-sterilized at the beginning, each time 1.25 kg per tank. When the first fruit of the tomatoes had walnut size, it should be based on plant growth. Adding diammonium phosphate and potassium sulfate to the disinfected chicken manure applied in the topdressing process, generally adding 0.1 kg of diammonium phosphate and 0.1 kg of potassium sulfate per 1 kg of disinfected chicken manure. The top dressing is stopped 1 month before the pull, and the foliar fertilizer can be traced 3 to 4 times during the growing season, once every 15 days.
6 Adjust the plants and pay attention to the pods in time after planting. When the first ear enlarges to a certain degree, if the plants grow too vigorously to affect the ventilation and light transmission, some or all of the leaves under the first panicle must be promptly destroyed. The main method is to use hanging vines and single stalk pruning to timely adjust the number of leaves, lateral branches, flowers, fruits and plant height, and keep the plants well ventilated and transparent, so that the plants always maintain a height of 1.8-2m.
7 pollination flowering artificial pollination is mainly artificial, can also be used to prevent hormones, 2,4-D and other hormones spray flowers or flowers, flowering during the day 10:00 to 11:00. Pay attention to thinning and thinning fruit and keep 3 to 4 fruits per panicle.
7 Pest Control
7.1 Insect Pest Control The greenhouse whitefly, spotted fly and aphid are the main insect pests of tomato. The main insect pests are insect prevention net isolation, yellow board trapping, silver gray film pest control, environmental regulation, cultivation methods and other physical control methods, combined with aerosol smoke smoke , pharmaceutical spray and other means for comprehensive prevention and control.
1 The whitefly used pesticides at the early stage of the whitefly occurrence and the density of the insect population was low. It can use 22% of dichlorvos 0.5kg per 667m2 to seal smoke in the greenhouse at night and kill some adults. The spray was treated with 25% buprofezin wettable powder 1000-1500 times, or 10% imidacloprid wettable powder 1000-1500 times.
When the damage rate of tomato leaf blade of Liriomyza huidoides was close to 5%, spraying control was performed. Can be used 40% green vegetable treasure EC 1000 ~ 1500 times liquid, 10% of imidacloprid WP 1000 times or 20% Confodic Concentrate 2000 times solvent can be used interchangeably.
7.2 The main diseases for disease prevention are seedling damping-off and damping-off, virus disease, late blight, gray mold, physiological calcium deficiency, etc. Disease resistant varieties, environmental regulation, cultivation measures, sulfur fumigation and other means should be used. The comprehensive control of chemical control.
1 Seed disinfection during seedling stage and Bacterial seed disinfection Using 0.1% chlorothalonil (75% wettable powder) + 0.1% seed dressing double (40% wettable powder) soaking for 30 minutes, use 50% of Fomebi for colonization. The wettable powder +25% metalaxyl WP was mixed 400 times with the same amount of water.
2 Virus disease seed disinfection: Wash with 10% tribasic sodium phosphate solution after soaking for 20 minutes; pay attention to prevent the transmission of aphids; during the seedling stage, spray 50~100mg/L to increase the disease resistance; 1.5% of plant disease spirit 1000 times liquid spray Prevention.
The 3rd epidemic disease was the key disease of tomato. Before the onset of the disease, it was found in the center of the disease or after the disease was found in the center. It was then taken out of the field to be destroyed. The diseased point was disinfected with lime, and 58% of metalaxyl MnZn WP was sprayed immediately. Doubling liquid or 72.2% Prokary Water 800 to 1000 times liquid and other agents for prevention and treatment.
4 Botrytis cinerea is susceptible to low temperature and high humidity, 65% metalaxyl wettable powder 600 times, 50% carbendazim wettable powder 800 times liquid can be used for prevention and treatment, and can also be used for fasting smoking.
5 Physiological calcium deficiency can be sprayed with 0.3% calcium chloride aqueous solution, twice a week
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, and marginal zone lymphoma.
We produce a series of complete intermediates for Ibrutinib, intermediate I (CAS No. 330786-24-8) and intermediate II (CAS No. 143900-44-1) etc.
All of our products are with stable production and strict quality control, making sure your experience with Sunshine Biotech is always enriching, satisfying and fulfilling.
At present, the cultivation of tomato is still mainly in the soil cultivation stage. The problem of large amount of labor, low efficiency, environmental pollution, continuous cropping obstacles, and continuous decline in output have become increasingly prominent. The adoption of organic ecological soilless culture techniques has unique features in solving the above problems. Now the key technologies are introduced as follows.