Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
Our company specializes in providing key intermediates for various APIs
Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
Key Intermediates , Pharmaceutical intermediates , Anticancer intermediates , Antitumor Intermediates XI AN RHINE BIOLOGICAL TECHNOLOGY CO.,LTD , https://www.rhinebiotech.com
for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
The processing of the end-opening parts of the pin type produced by a factory is always deformed, and various methods are tried, and no reasonable improvement can be obtained. Therefore, the factory found the technicians of Juhang Technology and hoped to solve this problem.
The premise of the problem: a pin-type part produced by a factory has grooves in all four directions of its circumference, and two long grooves are required to be opened in the symmetrical parts of the two sides of the pin. After the pin is slotted, due to the deterioration of the rigidity of the workpiece, under the action of the internal stress of the workpiece, the end of the workpiece has a phenomenon of rising deformation, and a batch of the workpiece is deformed by 100%. A qualified product, which is caused by the internal stress rebalance of the workpiece after processing.
Formulating a process plan: First, we must solve the problem of internal stress of the workpiece after machining. Before the workpiece is processed by JH vibration aging equipment , certain measures are taken for the workpiece. Firstly, the grooves on the upper side of the workpiece that are not open to the upper end surface are all machined and fixed, and then the slots that open to the upper end surface on both sides are not fully opened. Leave a width of 5-8mm at the end without milling and lacing, then use JH for vibration aging equipment.
Vibration aging treatment: After vibration aging, the stress inside the workpiece is rebalanced, and the internal stress of the workpiece is eliminated. When there is no stress inside the workpiece, the workpiece will not be deformed after reworking. So when we then cut off the 5-8mm two ribs left on the workpiece.
After inspection, the accuracy of the workpiece before and after the vibration is exactly the same, that is, there is no deformation before and after the vibration of the workpiece. After that, the same test was performed on the four workpieces, and the effect was exactly the same. Through the success of the JH vibration aging aging equipment experiment, the process was perfected, and all the workpieces processed according to this process were all qualified.
After the success of this experiment, the previously used hot-aging workpieces are now treated with JH vibration aging equipment, which brings great economic benefits to the plant. Vibration aging, energy saving and environmental protection, saving time and greatly improving production efficiency.