Pharmaceutical Antineoplastic Powder Dasatinib Monohydrate CAS 863127-77-9
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Model NO.: 863127-77-9
Customized: Non-Customized
Suitable for: Adult
Purity: >99%
Synonym: Dasatinib R; BMS-354825 Monohydrate
Mf: C22h28cln7o3s
Appearance: White Powder
Usage: Anti-Cancer
Delivery Time: 5-7 Days
Transport Package: Discreet Package
Origin: China
Powder: Yes
Certification: HSE, ISO 9001
State: Solid
CAS: 863127-77-9
MW: 506.02082
Assay(HPLC): 99.5%Min
Grade: Pharma Grade
MOQ: 10g
Trademark: Saichuang
Specification: Enterprise standard
Pharmaceutical Antineoplastic Raw Powder Dasatinib Monohydrate CAS 863127-77-9
Quick Detail
Product Name
Dasatinib Monohydrate Â
Synonym
Dasatinib R;BMS-354825 Monohydrate;Dasatinib monohydrate Â
CAS
863127-77-9 Â
MF
C22H28ClN7O3S Â
MW
506.02082 Â
Appearance
White Powder Â
Assay(HPLC)
99.5%min Â
Single impurity
≤0.1% Â
Usage
For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy. Â
MOQ
10g Â
Dasatinib Monohydrate Description:
Dasatinib monohydrate is a pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB.
BMS-354825 is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring.
BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Mechanism of Action:
Dasatinib, at nanomolar concentrations, inhibits the following kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Based on modeling studies, dasatinib is predicted to bind to multiple conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines representing variants of imatinib mesylate sensitive and resistant disease. Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression.
Dasatinib Monohydrate Benefits:
Dasatinib is a selective tyrosine kinase receptor inhibitor that is used in the therapy of chronic myelogenous leukemia (CML) positive for the Philadelphia chromosome. Dasatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.
A hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).
Advantage:
1, High quality with competitive price: 1) Standard:Enterprise Standard 2) All Purity≥98% 3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery 1) Parcel can be sent out within 24 hours after payment.Tracking number available 2) Secure and discreet shipment.Various transportation methods for your choice. 3) Customs pass rate ≥99% 4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world. 1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Peptides:
Peptide
Specification
Peptide
specification
MGF
2mg/vial
Ipamorelin
2mg/vial
PEG MGF
2mg/vial
Hexarelin
2mg/vial
CJC-1295 with DAC
2mg/vial
Sermorelin
2mg/vial
CJC-1295 without DAC
2mg/vial
Oxytocin
2mg/vial
PT-141
10mg/vial
TB500
2mg/vial
Melanotan I
10mg/vial
pentadecapeptide BPC 157
2mg/vial
Melanotan II
10mg/vial
Fragment 176-191
2mg/vial
GHRP-2
5mg or 10mg/vial
Triptorelin
2mg/vial
GHRP-6
5mg or 10mg/vial
Tesamorelin
2mg/vial
Gonadorelin
2mg or 10mg/vial
AOD-9604
2mg/vial
DSIP
2mg/vial
Follistatin 344
1mg/vial
Selank
5mg/vial
SNAP-8
Customized
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Various types of splints can be provided by our factory with 17 years OEM experience, such as AZ Splint , breathable splint, Vet Splint or Animal Splint, Finger Splint, Splint Set , IV arm board and Other Splints. Splint is a device used for support or immobilization of a limb or the spine. It can be used in multiple situations, including temporary immobilization of potentially broken bones or damaged joints and support for joints during activity.