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Model NO.: DAHUA
Assay: 99%
Payment Terms: Negotiable
Trademark: Dahua
Transport Package: 25kg/Drum
Specification: 26305-03-3
Origin: China
HS Code: 3822009000
Model NO.: DAHUA
Assay: 99%
Payment Terms: Negotiable
Trademark: Dahua
Transport Package: 25kg/Drum
Specification: 26305-03-3
Origin: China
HS Code: 3822009000
Enzyme Food Enzyme Preparations Pepstatin

Dear friend, thanks for visiting our website. This is Luna, I can check email and reply you at any time. Any items that you are interested in, pls feel free to contact me, I will reply you at the first time, and I will value every chance to be your reliable partner.

Product Name: Pepstatin A ~120'000 U/mg
Synonyms:    
Pepstatin A; pepstatin A from microbial source; Pepstatin (microbial product); Isovaleryl-Val-Val-Sta-Ala-Sta-OH; N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid; Pepstatin
CAS RN.:    
26305-03-3
EINECS:    247-600-0
Molecular Weight:    685.8921
Molecular Formula:    C34H63N5O9
Density:    1.117g/cm3
Melting Point(ºC):    233ºC (dec.)
Boiling Point(ºC):    997.6°C at 760 mmHg
Flash Point(ºC):    557.1°C
refractive_index:    1.504

Pepstatin is a potent inhibitor of aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations. Pepstatin A is well known to be an inhibitor of aspartic proteinases such as pepsin, cathepsins D and E. Except for its role as a proteinase inhibitor, however, the pharmacological action of pepstatin A upon cells remain unclear. Pepstatin A suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. Pepstatin A suppresses the formation of multinuclear osteoclasts dose-dependently. This inhibition of the formation only affected osteoclast cells, i.e., not osteoblast-like cells. Furthermore, pepstatin A also suppresses differentiation from pre-osteoclast cells to mononuclear osteoclast cells dose-dependently. This inhibition seems to be independent of the activities of proteinases such as cathepsin D, because the formation of osteoclasts was not suppressed with the concentration that inhibited the activity of cathepsin D. Cell signaling analysis indicated that the phosphorylation of ERK was inhibited in pepstatin A-treated cells, while the phosphorylation of IκB and Akt showed almost no change. Furthermore, pepstatin A decreased the expression of nuclear factor of activated T cells c1 (NFATc1). These results suggest that pepstatin A suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression.
Pepstatin is practically insoluble in water, chloroform, ether, and benzene, however it can be dissolved in methanol, ethanol, and DMSO with acetic acid, to between 1 and 5 mg/ml.

About us: 
Wuhan Dahua Weiye Pharmaceutical Chemical Co.,Ltd,  a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. Imaginechem can help our worldwide customers shorten the time and lower the cost of drug and medical device Research and Development through cost-effecitve and efficient outsourcing solutions.
 

Packaging & Delivery:
1. Shipping by express (FedEx, UPS, DHL, EMS), by air; By ship.
2. Shipment will be arranged within 24 hours after receiving the payment;
3. Pictures of the package will be sent to you then along with the tracking number; Super discreet packaging, to ensure safe delivery, 99% successful delivery rate is ensured. Delivery time: All of the orders will be packed within 24 hours after we get the payment usually it takes about3~5work days for you to get the parcel. Payment method: Bank wire, Western union, Moneygram
4. How to proceed order: First: Please let me know the itmes you are looking for, quantity, and the destination country. Second: You confirm all details, and offer us purchasing order; Third: We send the detail price of our product and offer the suitable shipping method for reference. Forth: You confirm the order and pay money 100% in advance and send us the detail address. Fifth: We arrange the shipment according to your requirements. Sixth: We offer after-sales service after you receive parcel
 

If you need this or you are interest in this kind of products, you are free to send me email or call me directly, we can talk more about the details of the products.
No matter you become a customer to me or not at last, you are welcome to inquire from me!
Thank you
Luna (^_^)
 
     
L-Tryptophan DL-Lysine hydrochloride N-Acetyl-DL-Methionine
     
L-Threonine DL-Leucine D-Valine
     
D-Methionine L-Phenylalanine D-Leucine
     
DL-Isoleucine L-Serine DL-Isoleucine
     
DL-Threonine L-Leucine DL-Methionine
     
D-Galactose L-Lysine D-Tryptophan
     
L-Lysine hydrochloride L-Lysine monohydrochloride D-Threonine
     
L-lysine Acetate Ammonium chloride L-(+)-Glutamic acid
     
L-Valine Urea Medication Grad L-Glutamic acid
     
L-Methionine N-Acetyl-L-Methionine D-Galactose
     
DL-Methionine N-Acetyl-DL-Methionine L-Alanine
     
L-(+)-Glutamic acid D-Alanine L-Serine
     
L-lysine Acetate D-Valine L-Valine
     
L-Alanine D-Leucine L-Lysine hydrochloride
     
D-Methionine D-Threonine L-Methionine
     
D-Threonine D-Methionine L-Tryptophan
     
D-Valine DL-Isoleucine D-Alanine
     
D-Isoleucine DL-Phenylalanine D-Leucine
     
D-Alanine DL-Valine DL-Phenylalanine
     
DL-Methionine DL-Tryptophan DL-Valine
     
L-Glutamic acid DL-Methionine DL-Threonine
     
D-Galactose L-lysine Acetate L-Phenylalanine
     
DL-Phenylalanine L-(+)-Glutamic acid L-Serine
     
L-Tryptophan L-Glutamic acid DL-Methionine
     
L-Tryptophan L-Valine L-Threonine
     
L-Threonine L-Alanine L-Tryptophan
     
Sodium caprylate L-Tryptophan D-Arabinose
     
N-Acetyl-L-Cysteine L-Threonine DL-Threonine
     
D-Arabinose Zinc Bacitracin L-lysine Acetate
     
DL-Threonine L-Methionine L-Glutamic acid
     
L-Threonine DL-Threonine  
Enzyme Food Enzyme Preparations Pepstatin
  Enzyme Food Enzyme Preparations Pepstatin

Dear friend, thanks for visiting our website. This is Luna, I can check email and reply you at any time. Any items that you are interested in, pls feel free to contact me, I will reply you at the first time, and I will value every chance to be your reliable partner.

Product Name: Pepstatin A ~120'000 U/mg
Synonyms:    
Pepstatin A; pepstatin A from microbial source; Pepstatin (microbial product); Isovaleryl-Val-Val-Sta-Ala-Sta-OH; N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid; Pepstatin
CAS RN.:    
26305-03-3
EINECS:    247-600-0
Molecular Weight:    685.8921
Molecular Formula:    C34H63N5O9
Density:    1.117g/cm3
Melting Point(ºC):    233ºC (dec.)
Boiling Point(ºC):    997.6°C at 760 mmHg
Flash Point(ºC):    557.1°C
refractive_index:    1.504

Pepstatin is a potent inhibitor of aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations. Pepstatin A is well known to be an inhibitor of aspartic proteinases such as pepsin, cathepsins D and E. Except for its role as a proteinase inhibitor, however, the pharmacological action of pepstatin A upon cells remain unclear. Pepstatin A suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. Pepstatin A suppresses the formation of multinuclear osteoclasts dose-dependently. This inhibition of the formation only affected osteoclast cells, i.e., not osteoblast-like cells. Furthermore, pepstatin A also suppresses differentiation from pre-osteoclast cells to mononuclear osteoclast cells dose-dependently. This inhibition seems to be independent of the activities of proteinases such as cathepsin D, because the formation of osteoclasts was not suppressed with the concentration that inhibited the activity of cathepsin D. Cell signaling analysis indicated that the phosphorylation of ERK was inhibited in pepstatin A-treated cells, while the phosphorylation of IκB and Akt showed almost no change. Furthermore, pepstatin A decreased the expression of nuclear factor of activated T cells c1 (NFATc1). These results suggest that pepstatin A suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression.
Pepstatin is practically insoluble in water, chloroform, ether, and benzene, however it can be dissolved in methanol, ethanol, and DMSO with acetic acid, to between 1 and 5 mg/ml.

About us: 
Wuhan Dahua Weiye Pharmaceutical Chemical Co.,Ltd,  a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. Imaginechem can help our worldwide customers shorten the time and lower the cost of drug and medical device Research and Development through cost-effecitve and efficient outsourcing solutions.
 

Packaging & Delivery:
1. Shipping by express (FedEx, UPS, DHL, EMS), by air; By ship.
2. Shipment will be arranged within 24 hours after receiving the payment;
3. Pictures of the package will be sent to you then along with the tracking number; Super discreet packaging, to ensure safe delivery, 99% successful delivery rate is ensured. Delivery time: All of the orders will be packed within 24 hours after we get the payment usually it takes about3~5work days for you to get the parcel. Payment method: Bank wire, Western union, Moneygram
4. How to proceed order: First: Please let me know the itmes you are looking for, quantity, and the destination country. Second: You confirm all details, and offer us purchasing order; Third: We send the detail price of our product and offer the suitable shipping method for reference. Forth: You confirm the order and pay money 100% in advance and send us the detail address. Fifth: We arrange the shipment according to your requirements. Sixth: We offer after-sales service after you receive parcel
 

If you need this or you are interest in this kind of products, you are free to send me email or call me directly, we can talk more about the details of the products.
No matter you become a customer to me or not at last, you are welcome to inquire from me!
Thank you
Luna (^_^)
 
     
L-Tryptophan DL-Lysine hydrochloride N-Acetyl-DL-Methionine
     
L-Threonine DL-Leucine D-Valine
     
D-Methionine L-Phenylalanine D-Leucine
     
DL-Isoleucine L-Serine DL-Isoleucine
     
DL-Threonine L-Leucine DL-Methionine
     
D-Galactose L-Lysine D-Tryptophan
     
L-Lysine hydrochloride L-Lysine monohydrochloride D-Threonine
     
L-lysine Acetate Ammonium chloride L-(+)-Glutamic acid
     
L-Valine Urea Medication Grad L-Glutamic acid
     
L-Methionine N-Acetyl-L-Methionine D-Galactose
     
DL-Methionine N-Acetyl-DL-Methionine L-Alanine
     
L-(+)-Glutamic acid D-Alanine L-Serine
     
L-lysine Acetate D-Valine L-Valine
     
L-Alanine D-Leucine L-Lysine hydrochloride
     
D-Methionine D-Threonine L-Methionine
     
D-Threonine D-Methionine L-Tryptophan
     
D-Valine DL-Isoleucine D-Alanine
     
D-Isoleucine DL-Phenylalanine D-Leucine
     
D-Alanine DL-Valine DL-Phenylalanine
     
DL-Methionine DL-Tryptophan DL-Valine
     
L-Glutamic acid DL-Methionine DL-Threonine
     
D-Galactose L-lysine Acetate L-Phenylalanine
     
DL-Phenylalanine L-(+)-Glutamic acid L-Serine
     
L-Tryptophan L-Glutamic acid DL-Methionine
     
L-Tryptophan L-Valine L-Threonine
     
L-Threonine L-Alanine L-Tryptophan
     
Sodium caprylate L-Tryptophan D-Arabinose
     
N-Acetyl-L-Cysteine L-Threonine DL-Threonine
     
D-Arabinose Zinc Bacitracin L-lysine Acetate
     
DL-Threonine L-Methionine L-Glutamic acid
     
L-Threonine DL-Threonine  
Enzyme Food Enzyme Preparations Pepstatin
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