Hypertrophy Peptide Myostatin GDF-8 Human Growth 1mg/Vial

Quick detail:

Product name: GDF-8 (Growth Differentiation Factor 8 Myostatin)
Purity: 85%
Specification: 1mg/vial, 10vials/box
Storage:2-8 degree centigrade refrigerator
Deliver:2 working day
Pacakge:Color box
Customized:accepted.
Country of Origin: China

Description:

GDF-8 (propeptide-Fc) is a myostatin inhibitor of muscle growth and development process. Myostatin is present in the healing process of muscles and its nature is to inhibit myogenesis (the process of formation of muscular tissue). Scientists have been studying a new method to enhance the repair and regeneration of both muscle and bone in certain injuries through a new recombinant myostatin propeptide.

Application

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.\

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

COA :

Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 2kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.

Our Service:
Payment method: Paypal, Western Union, Moneygram, TT.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3 days after payment

WHY CHOOSE US?
1, high quality with competitive price

1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

1)Parcel can be sent out in 1 day after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
4) Customs pass rate ≥ 99%!

3, We have clients throughout the world

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Any inquiries will be highly appreciated, meeting customer's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4)Best after-sales service!

 

 

Hypertrophy Peptide Myostatin GDF-8 Human Growth 1mg/Vial

Quick detail:

Product name: GDF-8 (Growth Differentiation Factor 8 Myostatin)
Purity: 85%
Specification: 1mg/vial, 10vials/box
Storage:2-8 degree centigrade refrigerator
Deliver:2 working day
Pacakge:Color box
Customized:accepted.
Country of Origin: China

Description:

GDF-8 (propeptide-Fc) is a myostatin inhibitor of muscle growth and development process. Myostatin is present in the healing process of muscles and its nature is to inhibit myogenesis (the process of formation of muscular tissue). Scientists have been studying a new method to enhance the repair and regeneration of both muscle and bone in certain injuries through a new recombinant myostatin propeptide.

Application

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.\

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

COA :

Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 2kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.

Our Service:
Payment method: Paypal, Western Union, Moneygram, TT.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3 days after payment

WHY CHOOSE US?
1, high quality with competitive price

1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

1)Parcel can be sent out in 1 day after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
4) Customs pass rate ≥ 99%!

3, We have clients throughout the world

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Any inquiries will be highly appreciated, meeting customer's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4)Best after-sales service!